Protein Details: Two-pore potassium channel 4

Protein ID

ICDB_Pro_1496

Protein Name

Two-pore potassium channel 4

Gene Name

TPK4; KCO4; At1g02510; T14P4.16

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

284 amino acids

AlphaFoldDB

AF-Q9FWX6-F1-model_v4.pdb

Function

Voltage-independent, instantaneously activating, potassium-selective plasma membrane ion channel. Open rectifier. Regulated by cytoplasmic pH and extra-cellular calcium. Has some permeability for Rb+ and NH4+, but none for Na+ or Li+.

Sequence

MEEENLLNENLLHPNESSPEETQVTTVSKSKWTILVLAMILLLVYLTFGVCTYSFFRDQFSGTETNLFVDAFYFSIVTFSTVGYGDIVPSTSTTKILTIVLVSTGVVFLDYLLNRVVSHVLSLQENAILDRINKTRNRAIRDHIAEDGKIRLKWKLCLAFCAVGLCVGSGALFLHVFERLDWLDSVYLSVISVTTVGYGDKTFKTVEGRGFAVFWLLLSTIAMATLFLYLAEMRIDRTTVMKLPPSESEFIVFKLRESGRISEDDIKQIVREFENLEEVPSSGS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Predominantly expressed in pollen.

DOI ID

10.1073/pnas.0401502101; 10.1038/35048500; 10.1111/tpj.13415; 10.1104/pp.126.4.1646; 10.1111/j.1365-313x.2006.02868.x; 10.1093/mp/ssn064

RefSeq

NP_171752.1